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Ownership Profile

Shareholder Breakdown
	Holders	Values ($)	% O/S	Shares
Institution	48	8,586,369.00	22.56	19,514,472
Mutual Fund	75	2,655,929.00	6.98	6,036,199

Institutional Shareholder Rotation
	Holders	Values Change ($)	% O/S	Shares Change
Buyers	16	376,379.00	4.52	855,408
Sellers	11	-181,371.00	5.47	-412,206
Net	--	195,008.00	-0.95	443,202

Institutional Shareholder Concentration
	Values ($)	% O/S	Shares
Top 10 Inst.	7,056,477	18.54	16,037,447
Top 20 Inst.	8,127,414.00	21.35	18,471,393
Top 50 Inst.	8,586,369.00	22.56	19,514,472
Total Inst.	8,586,369.00	22.56	19,514,472

Institutional Shareholder Style
	Holders	Values ($)	% O/S	Shares
GARP	25	3,879,635	45.18	8,817,350
Value	12	1,508,437	17.57	3,428,263
Deep Value	4	502,439	5.85	1,141,906
Growth	3	201,088	2.34	457,019
Index	2	606,437	7.06	1,378,267
Aggressive Growth	1	1,844,333	21.48	4,191,667
Yield	1	44,000	0.51	100,000

Top Holders: Institutional Investor
	Shares Held	% O/S	Shares Change	Filing Date
Tang Capital Management LLC	4,191,667	4.85	0	03/31/2009
BlackRock Global Investors	2,481,440	2.87	61,942	12/31/2009
Deutsche Investment Management Americas, Inc.	2,259,318	2.61	-158,800	12/31/2009
Talon Asset Management, Inc.	2,029,513	2.35	0	12/31/2009
Pennant Capital Management LLC	1,540,000	1.78	0	12/31/2009
Vanguard Group, Inc.	1,276,578	1.48	0	12/31/2009
Dimensional Fund Advisors, Inc.	743,606	0.86	-175,596	12/31/2009
State Street Global Advisors	546,243	0.63	-14,000	12/31/2009
D. E. Shaw & Co., Inc.	518,482	0.60	157,763	12/31/2009
Bridgeway Capital Management, Inc.	450,600	0.52	0	12/31/2009
Northern Trust Investments	442,092	0.51	-9,002	12/31/2009
The California Public Employees Retirement System	401,340	0.46	0	12/31/2009
Levin Capital Strategies LP	335,824	0.39	-1,541	12/31/2009
TIAA-CREF Asset Management LLC	253,393	0.29	0	12/31/2009
Columbia Management Advisors, Inc.	206,765	0.24	-50	12/31/2009

Ownership data is provided by FactSet, a third party service, and MiddleBrook Pharmaceuticals, Inc. does not maintain or provide information directly to this service.