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Ownership Profile

Shareholder Breakdown
	Holders	Values ($)	% O/S	Shares
Institution	44	1,317,197.00	13.72	11,866,625
Mutual Fund	40	242,449.00	2.52	2,184,206

Institutional Shareholder Rotation
	Holders	Values Change ($)	% O/S	Shares Change
Buyers	13	114,052.00	2.01	1,027,497
Sellers	9	-176,188.00	2.43	-1,587,271
Net	--	-62,136.00	-0.42	-559,774

Institutional Shareholder Concentration
	Values ($)	% O/S	Shares
Top 10 Inst.	1,151,876	12.00	10,377,248
Top 20 Inst.	1,293,345.00	13.47	11,651,729
Top 50 Inst.	1,317,197.00	13.72	11,866,625
Total Inst.	1,317,197.00	13.72	11,866,625

Institutional Shareholder Style
	Holders	Values ($)	% O/S	Shares
Value	25	590,329	44.82	5,318,281
GARP	6	7,092	0.54	63,888
Growth	4	2,853	0.22	25,699
Index	3	139,102	10.56	1,253,177
Deep Value	3	98,837	7.50	890,413
Yield	2	13,709	1.04	123,500
Aggressive Growth	1	465,275	35.32	4,191,667

Top Holders: Institutional Investor
	Shares Held	% O/S	Shares Change	Filing Date
Tang Capital Management LLC	4,191,667	4.85	0	04/15/2010
Pennant Capital Management LLC	1,540,000	1.78	0	03/31/2010
Vanguard Group, Inc.	1,244,763	1.44	0	03/31/2010
Talon Asset Management, Inc.	734,000	0.85	-1,295,513	03/31/2010
Renaissance Technologies LLC	720,900	0.83	581,100	03/31/2010
Dimensional Fund Advisors, Inc.	520,113	0.60	-4,000	04/30/2010
The California Public Employees Retirement System	400,000	0.46	-1,340	06/30/2010
D. E. Shaw & Co., Inc.	376,981	0.44	-141,501	03/31/2010
Levin Capital Strategies LP	347,402	0.40	11,578	03/31/2010
Credit Suisse (United States)	301,422	0.35	279,296	03/31/2010
TIAA-CREF Asset Management LLC	253,393	0.29	0	03/31/2010
Morgan Stanley & Co., Inc.	218,041	0.25	75,015	03/31/2010
Fortrinn Partners LLP	187,500	0.22	0	09/30/2009
Wexford Capital LLC	182,800	0.21	0	03/31/2010
North Star Investment Management Corp.	150,000	0.17	0	06/30/2010

Ownership data is provided by FactSet, a third party service, and MiddleBrook Pharmaceuticals, Inc. does not maintain or provide information directly to this service.